Amélia Pilar Rauter
Departamento de Química e Bioquímica (DQB) e Centro de Química e Bioquímica (CQB),
Faculdade de Ciências,
Universidade de Lisboa (FCUL)
Rua Ernesto de Vasconcelos, Campo Grande,Edifício C8, 5º Piso, 1749-016
Lisboa, Portugal
Telephone: +351 21 7590052; Mobile:+351 964408824;
E-mail: aprauter@fc.ul.pt; Skype name: amelia.pilar.rauter1
URL: http://webpages.ciencias.ulisboa.pt/~aprauter/
URL: http://cqb.fc.ul.pt/research/carbohydrate-chemistry/
Academic degrees: Habilitation
(Agregação), FCUL, 2002; Doktor der Technischen Wissenschaft, Technische
Universität Graz – Austria, 1982, stated equivalent to “Ph.D. in Chemistry“,
UTL, 1984; Graduation in Chemical Engineering, UTL, 1974; Professional positions: Associate
Professor, FCUL, (2003-); Invited Professor, Universidad de Valladolid, Spain, June 2016; Invited professor, Université Pierre et Marie Curie (UPMC – Paris VI), France, October 2013; Invited Professor, Polish Academy
of Sciences, August 2009, Warshaw, Poland; Invited Professor at the Université
Paris Sud 11, Orsay, France, June 2009; Lecturer of DQB-FCUL (2003-1984); Assistant Professor of Organic Chemistry, Institut für Organische Chemie,Technischen
Universität Graz - Austria (1983-1975); Student teacher, Instituto de Física e Matemática
(1974-1972); Founder member and Senior Researcher of Center of Chemistry and
Biochemistry (CQB-FCUL) (2001-); Member of CQB-FCUL Executive Committee (2014-);
Founder and Leader of CQB Carbohydrate Chemistry Group (2001-); Researcher of
the Centre of Mass Spectrometry, IST-UTL (1994-2001); Founder and Coordinator
of the Portuguese Carbohydrate Chemistry Group of the Portuguese Society of
Chemistry (2001-1995); Coordinator of DQB-FCUL Graduation in Chemistry (2004-2003);
Coordinator of the Graduation in Chemistry and of the Euromaster in Chemistry
and its specializations in Chemistry, Health and Nutrition, Green Chemistry, Analytical Chemistry,
Applied Electrochemistry (2011-2009).
1. ACHIEVEMENTS AND
HONORARY APPOINTMENTS
At the International level
- Secretary
of the European Carbohydrate
Organization since July 11, 2013, national representative and past-president (2001-2003);
- National representative
of the Founder of the International Carbohydrate Organization and founder of its Young Researcher Award in 2014;
- Member of the European Innovation
Partnership on Active and Healthy Ageing (EIP AHA) Action Group 3 –
Prevention of functional decline and frailty, established for the
implementation of its strategic plan for 2012-2015 and leader of its Faculty of
Sciences-University of Lisbon Consortium;
-Member of the COST Action CM1102 entitled
“Multivalent Glycosystems for Nanoscience MultiGlycoNano” since June 2013;
- Founder of the Iberian Carbohydrate Meetings, starting in 1999;
- European
Chemist, title given by the European Chemist registration
Board, established in 1992 by the European Communities Chemistry Council, 1998.
Networks
1. Member of the steering committee of the ESF
funded network Euroglycoforum, and Executive of the network interest group
Glycochemistry (2009-2014);
2. Member of PCBNet - Stem Cells, Prion Proteins
and Alzheimer's Disease: A Prion Chemical Biology Network, Sheffield, UK
(2011-2013);
3. Member of the research network entitled
“Valuation of Portuguese Salvia species in terms of food quality and funcional
food production”, approved by The British Council Convenium/Fundação para a
Ciência e Tecnologia with The University of Sheffield (2008-2009).
Editorial board
membership and editorial activities
As Editor
1. Editor of the Royal
Society of Chemistry Book Series Carbohydrate Chemistry – Chemical and
biological approaches – invited by the RSC to relaunch the series, since 2008;
2. Associate Editor of Mediterranean Journal of Chemistry since 2012;
3. Guest editor of Topics in Current Chemistry for volumes 294 and 295 dedicated to Carbohydrates in Sustainable Development, 2010;
4. Guest editor of the European Journal of Organic Chemistry for the publication of the contributions dedicated to the centenary of the Portuguese Society of Chemistry, 2013;
5. Guest editor of Pure and Applied Chemistry for the publication of the contributions dedicated to the 19th European Symposium of Organic Chemistry, 2015;
6. Guest editor of Pure and Applied Chemistry for the publication of the contributions dedicated to the XXVIII International Carbohydrate Symposium, 2016.
As member of editorial/advisory boards
1. Member of the editorial board of Medicinal Chemistry since 2017;
2. Member of the editorial board of Pure and Applied Chemistry since 2016;
3. Member of the editorial board of the International Journal of Bioorganic Chemistry & Molecular Biology since 2016;
4. Member of the advisory board of European Journal of Organic Chemistry, starting 2013;
5. Member of the editorial board of Carbohydrate Research until 2005;
6. Member of the editorial board of the Journal of Carbohydrate Chemistry since 1998;
7. Member of the editorial board of the Journal Natural Products – an Indian Journal, since 2006.
IUPAC
- Secretary of IUPAC Organic and Biomolecular Division (III) (since 2016);
- Secretary of the Subcommittee on Biomolecular Chemistry of IUPAC Organic and Biomolecular Division (III) (2012-2015);
- Titular member of IUPAC Division (VIII) of Chemical Nomenclature and Structure Representation (2011-2015) and national representative (2016-2018);
- Associate member of IUPAC Interdivisional Committee on Terminology, Nomenclature and Symbols (ICTNS) until 2014 and Division VIII representative in ICTNS (2014-2015);
- Associate member of IUPAC Division (III) of Organic and Biomolecular Chemistry, starting 2014.
At the national level
-Awarded with the Mention
of Excellency (Menção Excelente) by the Faculty of Sciences of the
University of Lisbon in both evaluations by curricular ponderation in the periods
2004-2007 and 2008-2011;
- Member of the LisbonLiving+ Consortium Executive Committee (2013-Sept.2014). This consortium was established for the application to a EIT KIC on Healthy Life and Active Ageing;
- Member of the UL
Network on Health (2014 -);
- Member of the research core team of the
FCT-Ph.D. Program entitled Catalysis and Sustainability (CATSUS), 2013;
- Member of the Steering Committee of the Technology Transfer Unit of the
University of Lisbon UL-INOVAR (2009-2013);
- Member of the Executive Committee of CQB-FCUL since Feb. 2014.
2.
RESEARCH INTERESTS
Development of molecular entities and processes to
promote an active and healthy ageing and to act on the prevention of functional
decline and frailty. Design and synthesis of new
leads with new mechanisms of action or alternatively their isolation from
natural resources and structure elucidation. Some promising molecules for metabolic
(diabetes), degenerative diseases (Alzheimer´s and Prion diseases, cancer) and
infection are currently under investigation.
3.
RESEARCH PROJECTS AND OTHER
EUROPEAN FUNDED PROGRAMS
Has coordinated/participated as PI of FCUL in projects sponsored by EU, IUPAC,
NATO, FCT, QREN, FLAD, CRUP, among other funding agencies and programs and with
national and international companies (42 projects). The projects funded by EU
and IUPAC are highlighted below:
Projects approved by the
European Union
1.
“Diagnostic and
Drug Discovery Initiative for Alzheimer’s Disease”, Industry-Academia
Partnerships and Pathways (IAPP), FP7-PEOPLE-2013-IAPP, Project Nr. 612347,
2014-2018, PI from FCUL.
2.
“PERsonalised ICT
supported Service for Independent Living and Active Ageing”, Small or
medium-scale focused research project (STREP), FP7-ICT-2013-10, Project Nr. 610359,
2013-2016, PI from FCUL.
3. “Healthy ageing
with innovative functional foods/leads for degenerative and metabolic diseases
(INNOVAFUNAGEING)”, approved in the “Invitation for Commitments to the
Strategic Implementation Plan of the European Innovation Partnership on Active
and Healthy Ageing (EIP AHA) - Action A3”, 2012-2015, Coordinator.
4. “11th. European Carbohydrate Symposium”, European
Commission -Accompanying Measure, Quality of Life and Management of Living
Resources, 2001, Coordinator.
5.
“EuroConferences on Carbohydrates in Drug Research”, Commission of the
European Communities - Training and Mobility Research Programme, 1997,
Coordinator from FCUL.
6.
“EuroConferences on Carbohydrate Mimics”, Commission of the European
Communities – Human Capital and Mobility Programme, 1999, Coordinator from
FCUL.
7. “Synthese de Molecules Biologiquement Importantes a partir des Glucides”, EEC Science Program, 1991–1994,
PI-FCUL.
IUPAC Projects
8. “Recommendations on Nomenclature of Flavonoids”,
IUPAC project No. 2009-018-2-800 (2010-), Chair.
9. “Rules for Abbreviation of Protecting Groups”, IUPAC Project No. 2011-044-1 (2012-2013), team member.
10. “Revision and extension of IUPAC Recommendations on Carbohydrate Nomenclature”, IUPAC Project No. 2012-039-1 (2013-), team member.
11. “Revision and extension of IUPAC Recommendations on Carbohydrate Nomenclature”, Project No 2015-035-2-800 (2015-), team member.
12. “Healthy life and active ageing – the contribution of functional food ingredients”, Project No. 2013-054-2-300 ( 2013 -), Chair.
4.
ORGANIZATION OF INTERNATIONAL CONFERENCES
Chairperson of the following International Conferences: 19th European Symposium on Organic Chemistry, 2015; 6th Spanish-Portuguese-Japanese Organic Chemistry Symposium, 2012; Glycosciences in the International Year of Chemistry – Applications to Human Health and Disease, 2011; Carbohydrates as Organic Raw Materials V – Building a Sustainable Future (CORM V), 2009; 11th. European Carbohydrate Symposium
(EUROCARB XI) 2001; 2nd Euroconference on Carbohydrates in Drug Research (ECCDR2), 2000; Phytochemical Society of Europe Meeting entitled “Natural Products from the Plants and Marine Organisms of the Mediterranean and Atlantic Seaboard: Isolation, Synthesis and Industrial Applications”, 2000; 1st International Meeting of the Portuguese Carbohydrate Chemistry Group, 1995, and has been member of the scientific and organizing committees of a number of
International and National Meetings.
5.
TEACHING ACTIVITIES
- She created the Training Course in Ciências on Processes of Nutrition, Environment and Health, an interdisciplinary course lectured by experts from Nutrition, Medicine, Chemistry and Biochemistry, with the participation of companies contributing with cases of success in the areas of nutrition and health, documented by company experts, 2017.
- She had the initiative to create the EuroMaster in Chemistry with specialization in Chemistry, Health and Nutrition of DQB-FCUL, structured this course and was responsible for its implementation (2006).
- She lectured and has been responsible for Organic Drug Synthesis and Molecular Glycobiology, optional courses of the EuroMaster in Chemistry with specialization in Chemistry, Health and Nutrition of DQB-FCUL since 2006.
- She lectured and has been responsible for the course Organic Chemistry I (1st year, Graduation in Chemistry and Technological Chemistry) since 2002.
- She lectured and has been responsible for Carbohydrate Chemistry (3rd year, Graduation in Chemistry, optional), lectured since its implementation in 2002.
- She has organized the following post-graduation 3 day courses:
1. “Structure and Conformation
of Carbohydrates. NMR and Molecular Recognition”, lectured by Jesus Jiménez
Barbero, Filipa Marcelo e Ana Arda (Centro de Investigaciones Biológicas, CSIC,
Spain), in 2011;
2. “Industrial Drug Research” lectured by Dr. Hans Peter Wessel,
Hoffmann-La Roche, Basel, Switzerland, 2010;
3. “Molecular Mechanisms of Drugs” lectured by Prof. Beat Ernst,
Universidade de Basel, Switzerland, in 2009.
6. SUPERVISION OF Ph.D. THESIS, MASTER THESIS AND POSTDOCTORAL FELLOWSHIPS
Supervisor of 20 Ph.D. theses, and of five additional Ph.D.students, who
are currently carrying out their research. Also supervised 19 Master thesis and
10 Post-Doc fellowships granted by Fundação para a Ciência e a Tecnologia (FCT).
Supervisor of the following Ph.D. theses (when acting as co-supervisor,
this will be mentioned case by case):
1. Catarina Vizetto Duarte, "Antitumoural activity of Cystoseira species: insights into the mechanism of action", SFRH/BD/81425/2011, supervision of Prof. Joao Varela (Universidade do Algarve), co-supervision of Prof. Amélia Rauter (FCUL), Universidade do Algarve, 2016.
2. Ana Rita Xavier de Jesus, "Chemoenzymatic synthesis of sodium-glucose co-transporters sugar-based inhibitors for the treatment of diabetes", SFRH/BD/78236/2011, co-supervision of Prof. Jian Liu (University of North Caroline, USA) and Prof. Timothy Dore (New York University of Abu Dhabi), Faculdade de Ciências, Universidade de Lisboa, 2015.
3. Rui Miguel Galhano dos Santos Lopes, "The first synthesis of glycosylflavanones catalysed by praseodymium triflate: a straightforward approach to potential antidiabetic agents", SFRH/BD/30699/2006, co-supervision of Prof. Jorge Justino (Instituto Politecnico de Santarem/Escola Superior Agraria), Universidade de Lisboa, 2013.
4. Isabel Maria Martins Horta Branco, "Study of the bioactive extracts of Salvia sclareoides Brot. and Asteriscus vogelii (Webb.) Walp. and research on their bioactive principles", Universidade de Lisboa, 2011.
5. Nuno Manuel Ribeiro Martins Xavier, "Synthesis of new sugar derivatives containing an a,ß-unsaturated carbonyl system in their structure and biological evaluation", SFRH/BD/39251/2007, co-supervision of Dr. Yves Queneau (Université de Lyon, France), Universidade de Lisboa, 2011.
6. Ana Catarina de Araújo Silva, "Polyfunctionalized carbohydrate-derived scaffolds for the production of libraries of bioactive compounds", SFRH/BD/17815/2004, co-supervision of Prof. Francesco Nicotra (Università degli Studi di Milano-Bicocca, Italy), Universidade de Lisboa, 2010.
7. Ana Catarina Simão, "Selective Anchoring of Cyclic Thionocarbamates on Ketohexoses", SFRH/BD/25891/2005, co-supervision of Prof. Patrick Rollin (Université d´Orléans, France) and Prof. Jorge Justino (Instituto Politécnico de Santarem/Escola Superior Agraria), Université d’Orléans, 2009.
8. Sandrina Isabel Ribeiro Martins da Silva, "Carbohydrate-based 1,3-oxazoline-2-thiones as original bioactive structures. Synthesis and reactivity", SFRH/BD/16937/2004, co-supervision of Prof. Jorge Justino (Instituto Politecnico de Santarem/Escola Superior Agraria) and Prof. Patrick Rollin (Université d´Orléans, France), Universidade de Lisboa, 2009.
9. Filipa Margarida Barradas de Morais Marcelo, "Total Synthesis and Stereochemical Assignment of Miharamycins", SFRH/BD/17775/2004, co-supervision of Prof. Pierre Sinaÿ (Universite Pierre et Marie Curie, Paris, France), and of Prof. Jorge Justino (Instituto Politecnico de Santarem/Escola Superior Agraria), Universidade de Lisboa, 2009.
10. João Carlos Falcão Sardinha, "Synthesis of gem-difluorocarbasugars", SFRH/BD/17839/2004, co-supervision of Prof. Pierre Sinaÿ (Universite Pierre et Marie Curie, Paris, France), Universidade de Lisboa, 2009.
11. Susana Dias Lucas, "Oxetane delta-Amino Acids: Synthesis and Derivatization", SFRH/BD/16592/2004, co-supervision of Dr. Hans Peter Wessel (Hoffmann-La Roche, Switzerland), Universidade de Lisboa, 2009. Susana is post-Doc at Faculdade de Farmacia da Universidade de Lisboa.
12. Tânia Vanessa Santos de Almeida, "Synthetic approaches for the condensation of sugars with O-, N- and S-nucleophiles", SFRH/BD/3306/2000, Universidade de Lisboa, 2006.
13. Alice Isabel Mendes Martins, "Contribution to the phytochemical study of plants endemic to Madeira Island: Flavonoids and 10lkaloids from Genista tenera", co-supervision of Prof. Jorge Justino (Instituto Politécnico de Santarém) and of Prof. Carlos Borges (DQB-FCUL), Universidade de Lisboa, 2006.
14. Orlando da Silva Pinto, "Nitrenium ion chemistry: Investigation of the intramolecular cyclization of ethyl omega-(azidophenil)-2-phenylalcanoates", Universidade de Lisboa, 2003.
15. Tana Lukeba Canda, "Synthesis of sugars containing butenolides in their structure", Universidade de Lisboa, 2002.
16. Maria da Graça Ribeiro Campos, "Polen characterization by phenolics profile and bioactivity studies", supervision of Prof. Dout. Proença da Cunha (Faculdade de Farmácia, Universidade de Coimbra) and co-supervision of Prof. Amelia Pilar Rauter, 1997
17. Maria Isabel Ismael, "Synthesis of unsaturated bioactive moieties in carbohydrates", Universidade da Beira Interior, 1997.
18. José Albertino Figueiredo, "Synthesis of Pseudo-C-Nucleosides", Universidade da Beira Interior, 1997.
19. Maria João Dias Rua Ferreira, "Synthesis of the hexopyranosidic sugar moiety analogues of Miharamycin", Universidade de Lisboa, 1996.
20. Ana Cristina da Silva Fernandes, "Synthesis of the branched hexopyranosidic moiety of Amipurimycin. Development of novel methods for deoxygenation and for acetonation", Universidade de Lisboa, 1996.
7. Ph.D. STUDENTS CURRENTLY UNDER MY SUPERVISION
1. João Manuel Ventura Cardoso de Barros, "Macrophage ligands type lectine-galactose (MGL): chemical synthesis and molecular recognition studies by NMR", co-supervised by Dr Filipa Marcelo (UNL), started in 2015.
2. Vasco Miguel Candeias Cachatra "New synthetic strategies and structural optimisation of the sugar moiety from a selective butyrylcholinesterase inhibitor ", SFRH/BD/90359/2012.
3. Catarina Alexandra dos Santos Dias, "New molecular entities for multitarget therapy: infectious and neurodegenerative diseases", BDE Grant, co-supervision of Dr. Dália Barbosa (CIPAN), SFRH/BDE/51998/2012.
4. João Pedro Almeida Pais, "Development of new antibiotics eficiente against Bacillus anthracis", BDE Grant, co-supervision of Dr. Dália Barbosa (CIPAN) and Dr. Ricardo Dias (BIOFIG-FCUL), SFRH/BDE/51957/2012.
5. Ana Marta de Jesus Gomes de Matos, "From a multitarget antidiabetic glycosyl isoflavone towards new molecular entities against Diabetes and Alzheimer’s disease: generation of lead series and target assessment", co-supervision of Prof. Paula de Macedo (FCM-UNL), SFRH/BD/93170/2013.
8. PUBLICATIONS
Author of ca 130 publications and 12 published/granted patents, we highlight some of the peer reviewed publications and book chapters in the last ten years. Most of the published papers fall within the areas of carbohydrate chemistry, organic chemistry, medicinal chemistry, multidisciplinary chemistry and applied chemistry.
Papers (2017-2005)
2017
1. A. M. de Matos, M. P. Macedo, A. P. Rauter, Bridging type 2 diabetes and Alzheimer’s disease: assembling the puzzle pieces in the quest for the molecules with therapeutic and preventive potential, 2017, in press; https://www.ncbi.nlm.nih.gov/pubmed/2842229
2. M. T. Blázquez Sanchez, A. M. de Matos, A. P. Rauter, Exploring Anti-Prion Glyco-Based and Aromatic Scaffolds: A Chemical Strategy for the Quality of Life, 2017, Molecules, 22(6), article ID: 864, DOI: 10.3390/molecules22060864i864
3. A. R. Jesus, D. Vila-Viçosa, M. Machuqueiro, A. P. Marques, T. M. Dore, A. P. Rauter, Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation Journal of Medicinal Chemistry, 2017, 60, 568-
4. A. M. Matos, J. S. Cristóvão, D. V. Yashunsky, N. E. Nifantiev, A. S. Viana, C. M. Gomes and A. P. Rauter, Synthesis and effects of flavonoid structure variation on amyloid-β aggregation, Pure and Applied Chemistry, 2017, 89 (9), in press.
5. D. Batista, P. L. Falé, M. L. Serralheiro, M. E. Araújo, C. Dias, I. Branco, C. Grosso, J. Coelho, A. Palavra, P. J. A. Madeira, A. Martins, A. P. Rauter, Phytochemical Characterization and Biological Evaluation of the Aqueous and Supercritical Fluid Extracts from Salvia sclareoides Brot., Open Chemistry, 2017, 15, 82-91.
2016
6. M. J. Rodrigues, V. Neves, A. Martins, A. P. Rauter, N. R. Neng, J. M. F. Nogueira, J. Varela, L. Barreira, L. Custodio, In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis), Food Chemistry, 2016, 200, 322-329.
7. P. Dias, A. C. Figueiredo, A. Martins, A. P. Rauter. Flower colour and essential oil composition in Erica australis L. grown in Portugal. Journal of Essential Oil Bearing Plants, 2016, 19(4), 1013-1018.
8. A. R. Jesus, A. P. Marques, A. P. Rauter, An easy approach to dihydrochalcones via chalcone in situ hydrogenation, Pure and Applied Chemistry, 2016, 88(4), 349-361 (IF 2.615)
9. C. Vizetto-Duarte, L. Custodio, K. Gangadhar, J. H. G. Lago, C. Dias, A. M. Matos, N. Neng, J. M. F. Nogueira, L. Barreira, F. Albericio, A. P. Rauter, J. Varela, Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage, Phytomedicine, 2016, 23(5), 550-557.
10. C. Vizetto-Duarte, L. Custodio, L. Barreira, M. M. da Silva, A. P. Rauter, F. Albericio, J. Varela, Proximate biochemical composition and mineral content of edible species from the genus Cystoseira in Portugal, Bot. Mar., 2016, 59(4), 251-257.(IF 1.25)
11. C. Vizetto-Duarte, L. Custodio, G. Acosta, J. H. G. Lago,T. R. Morais, C. B. de Sousa, K. Gangadhar, M. J. Rodrigues, H. Pereira, R. T. Lima, M. H. Vaconcelos, L. Barreiro, A. P. Rauter, F. Alberício, J. Varela, Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds. PEERJ, 2016, 4, article e1704, DOI:10.7717/peed.1704
12. M. Illario, A. S. Maione, M. R. Rusciano, E. Goessens, A. Rauter, N. Braz, H. Jager-Wittenaar, C. Di Somma, M. Soprano, L. Vuolo, P. Campiglia, M. A. Succi, H. Griffiths, T. Hartman, A. Colao, R. Roller-Wirnsberger, An integrated nutritional approach as a sustainable tool to prevent malnutrition in older people and promote active and healthy ageing. The EIP on AHA Nutrition Action Group, Advances in Public Health, 2016, ID 5678782, 9 pages (http://dx.doi.org/10.1155/2016/5678782).
13. A. P. Rauter, The molecules of life. In: H2020: Special reports, http://horizon2020projects.com/special-reports/the-molecules-of-life
14. A. P. Rauter, The Molecules of Life. In: Horizon 2020 Projects: Portal, 2016, vol 10, 194-195. (www.horizon2020publications.com/H10/194).
2015
15. V. Cachatra, A. Almeida, J. Sardinha, S. D. Lucas, A. Gomes, P. D. Vaz, M. H. Florencio, R. Nunes, D. Vila-Viçosa, M. J. Calhorda, A. P. Rauter, Wittig Reaction: Domino Olefination and Stereoselectivity DFT Study. Synthesis of the Miharamycins’ Bicyclic Sugar Moiety, Org. Lett., 2015, 17(22), 5622-5625, DOI: 10.1021/acs.orglett.5b02849.
16. S. Schwarz, B. Siewert, R. Csuk, A. P. Rauter, New antitumor 6-chloropurine nucleosides inducing apoptosis and G2/M cell cycle arrest, Eur. J. Med. Chem. 2015, 90, 592-602, DOI: 10.1016/j.ejmech.2014.11.019
17. L. Unione, B. X. Xu, D. Diaz, S. Martin Santamaria, A. Poveda, J. Sardinha, A. P. Rauter, Y. Blériot, Y. M. Zhang, F. J. Cañada, M. Sollogoub, J. Jiménez-Barbero, Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-l-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings, 2015, Chem. Eur. J. 21(29), 10513-10521, DOI: 10.1002/chem.201501249
18. C. Vizetto-Duarte, H. Pereira, C. Bruno de Sousa, A. P. Rauter, F. Alberício, L. Custódio, L. Barreira, J. Varela, Fatty acid profile of different species of algae of the Cystoseira genus: a nutraceutical perspective. Natural Product Research, 2015, 29(13), 1264-1270, DOI: 10.1080/14786419.2014.992343
19. L. Custódio, F. H. Pereira, M. J. Rodrigues, L. Barreira, A. P. Rauter, F.Alberício, J. Varela, Botryococcus braunii and Nannochloropsis oculata extracts inhibit cholinesterases and protect human dopaminergic SH-SY5Y cells from H2O2-induced cytotoxicity, J. Appl. Phycology, 2015, 27 (2), 839-848, DOI: 10.1007/s10811-014-0369-4
20. P. Dias, P. L. Falé, A. Martins, A. P. Rauter, Digestibility and Bioavailability of the Active Components of Erica australis L. Aqueous Extracts and Their Therapeutic Potential as Acetylcholinesterase Inhibitors, Evidence-Based Complementary and Alternative Medicine 2015, Article ID 854373, 7 pages, DOI: 10.1155/2015/854373
21. D. Batista. P. L. Fale´,M. L. Serralheiro, M. E. Araujo, P. J. A. Madeira, C. Borges, I. Torgal, M. Goulart, J. Justino, A. Martins, A. P. Rauter, New In Vitro Studies on the Bioprofile of Genista tenera Antihyperglycemic Extract, Nat. Prod. Bioprospect., 2015,, 5(6), 277-285
22. M. J. Rodrigues, A. Soszynski, A. Martins, A. P. Rauter, N. R. Neng, J. M. F. Nogueira, J. Varela, L. Barreira, L. Custódio, Unravelling the antioxidant potential and the phenolic composition of different anatomical organs of the marine halophyte Limonium algarvense, Ind. Crops Prod. 2015, 77, 315-322, DOI: 10.1016/j.indcrop.2015.08.061
23. S. Flitsch, S. Perez, M. Aebi, T. Alamäe, K. Baldenius, O. Blixt, B. Christensen, H. Clausen, J. Codee, J. Čopíková, P. Delannoy, A. Dell, S. Eichhorn, T. Feizi, R. Field, J. Finne, C. Galan, C. Hokke, O. Hindsgaul, L. Joshi, H. Kamerling, N. Karlsson, L. Kjellén, J. Kuballa, M. Lahmann, S. László, G. Lauc, U. Lindahl, A. Merry, C. Merry, J.-C. Michalski, A. Molinaro, J. Mucha, F. Nicotra, G. Opdenakker, H. Overkleeft, G. Palamarczyk, M. Palcic, S. Penadés, S. Petrescu, A. P. Rauter, N.-C. Reichardt, P. Rudd, P. Seeberger, B. Turnbull, J. Turnbull, C. Unverzagt, W. Willats, I. Wilson, R. Woods, A Roadmap for Glycoscience in Europe – white paper, ed. Euroglycoforum, Manchester 2015.
2014
24. B. Xu, L. Unione, J. Sardinha, S. Wu, M.
Ethève-Quelquejeu, A. P. Rauter, Y. Blériot, Y. Zhang, S. Martín-Santamaría, D.
Diaz, J. Jiménez-Barbero, M. Sollogoub, Gem-difluoro-carbadisaccharides:
restoring the exo-anomeric effect, Angew. Chem. Int. Ed. 2014, 53, 9597 – 9602.
IF:11.336
25. R. Jesus, C. Dias, A. M. Matos, R. F. M. Almeida, A. S. Viana, F. Marcelo, R. T. Ribeiro, M. P. Macedo, C. Airoldi, F. Nicotra, A. Martins, E. J. Cabrita, J. Jimenéz-Barbero, A. P. Rauter, Exploiting the Therapeutic Potential of 8-ß-D-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity and Molecular Interaction with IAPP and Aß1-42, J. Med. Chem. 2014, DOI: http://dx.doi.org/10.1021/jm501069h
26. S. Schwarz, R. Csuk, A. P. Rauter, Microwave-assisted synthesis of novel purine nucleosides as selective cholinesterase inhibitors,Org. Biomol. Chem. 2014, 12 (15), 2446 – 2456. IF:3.487
27. N. M. Xavier, A. P. Rauter, Enantioselective synthesis in carbohydrate-based drug discovery, Curr. Topics Med. Chem. 2014, 10, 1235 - 1243. IF: 3.453
28. S. Schwarz, B. Siewert, N. M. Xavier, A. R. Jesus, A. P. Rauter, R. Csuk, A “natural” approach: Synthesis and cytoxicity of monodesmosidic glycyrrhetinic acid glycosides, Eur. J. Med. Chem. 2014, 72, 78 - 83. IF:3.432
29. N. M. Xavier, S. Schwarz, P. D. Vaz, R. Csuk, A. P. Rauter, Synthesis of Purine Nucleosides From D-Glucuronic Acid Derivatives and Evaluation of Their Cholinesterase Inhibitory Activities, Eur. J. Org. Chem. 2014, 13, 2770 – 2779, DOI: 10.1002/ejoc.201301913
30 A. P. Rauter, M. Ennis, K.-H. Hellwich, B. J. Herold, D. Horton, G. Moss, I. Schomburg, Nomenclature of Flavonoids IUPAC Recommendations 2014, Pure Appl. Chem. 2014, accepted, IF:3.112
31. V. Cachatra, A. P. Rauter, Revisiting Wittig olefination and aza-Wittig reaction for carbohydrate transformations and stereocontrol in sugar chemistry, Curr. Org. Chem. 2014,18(13), 1731-1748. IF:2.537
32. L. Custódio, F. Soares, H. Pereira, L. Barreira, C. Vizetto-Duarte, M. J. Rodrigues, A. P. Rauter, F. Alberício, J. Varela, Fatty acids composition and biological activities of Isochrysis galbana T-ISO, Tetraselmis sp. and Scenedesmus sp.: possible application in the pharmaceutical and functional food industries, J. Appl. Phycol. 2014, 26(1),151-161. IF: 2.492
33. A. Martins, R. Mignon, M. Bastos, D. Batista, N. R. Neng, J. M. F. Nogueira, C. Vizetto-Duarte, L. Custódio, J. Varela, A. P. Rauter, In vitro Antitumoral Activity of Compounds Isolated from Artemisia gorgonum Webb, Phytother. Res. 2014, 28(9), 1329-1334. IF: 2.397
34. S. Silva, F. V. M. Silva, J. Justino, A. P. Rauter, P. Rollin, A. Tatibouet, Synthesis and antimicrobial evaluation of oxazole-2(3H)-thione and 2-alkylsulfanyl-1,3-oxazole derivatives, Heterocycles 2014, 88(2), 1013-1028, DOI: 10.3987/COM-13-S(S)56
35. C. Vizetto-Duarte, M. J.Rodrigues, H. Pereira, N. Neng, J. M. F. Nogueira, H. Vasconcelos, G. Acosta, L. Custodio, L . Barreira, A. P. Rauter, F. Albericio, J. Varela, Antitumoural activity of Cystoseira species: Insights into the mechanism of action, Planta Med. 2014, 80(16), 1358-1358, DOI: 10.1055/s-004-27987
36. V. Ferreira, C. A. Reis, S. Perez, A. P. Rauter, P. A. Videira, Meeting report on EMBO Workshop: Glycobiology and glycochemistry, applications to human health and disease, Glycobiology 2014, 24(9), 782-783, DOI: 10.1093/glycob/cwu070
2013
37. F. Marcelo, C. Dias, A. Martins, P. J. Madeira, J. Jorge, M. H. Florêncio, F. J. Cañada, Eurico J. Cabrita, J. Jiménez-Barbero, A. P. Rauter, Molecular Recognition of Rosmarinic Acid from Salvia sclareoides Extracts by Acetylcholinesterase. A New Binding Site Detected by NMR, Chem. Eur. J. 2013, 19(21), 6641-6649.
38. C.Airoldi, E. Sironi, C. Dias, F. Marcelo, A. Martins, A. P. Rauter, F. Nicotra, J. Jimenez-Barbero, Natural compounds against Alzheimer’s Disease: Molecular recognition of Salvia sclareoides extract and its major component, rosmarinic acid, with Aß1-42 peptide, as investigated by NMR, Chem.-Asian J. 2013, 8(3), 596-602.
39. L. B. Roseiro, C. S. Tavares, J. C. Roseiro, A. P. Rauter, Antioxidants from aqueous decoction of carob pods biomass (Ceretonia siliqua L.): Optimisation using response surface methodology and phenolic profile by capillary electrophoresis, Ind. Crops Prod. 2013, 44, 119-126, DOI:10.1016/j.indcrop.2012.11.006
39. L. B. Roseiro, C. S. Tavares, J. C. Roseiro, A. P. Rauter, Antioxidants from aqueous decoction of carob pods biomass (Ceretonia siliqua L.): Optimisation using response surface methodology and phenolic profile by capillary electrophoresis, Ind. Crops Prod. 2013, 44, 119-126, DOI:10.1016/j.indcrop.2012.11.006
40. L. B. Roseiro, L. C. Duarte, D. L. Oliveira, R. Roque, M. G. Bernardo-Gil, A. I. Martins, C. Sepúlveda, J. Almeida, M. Meireles, F. M. Gírio, A. P. Rauter, Supercritical, ultrasound a nd conventional extracts from Carob (Ceratonia siliqua L.) Biomass: Effect on the phenolic profile and antiproliferative activity, Ind. Crops Prod. 2013, 47, 132-138
41. R. Santos, N. M. Xavier, J. Bordado, A. P. Rauter, Efficient and first regio- and stereoselective direct C-glycosylation of a flavanone catalysed by Pr(OTf)3 under conventional heating, or ultrasound irradiation, Eur. J. Org. Chem. 2013, 8, 1441-1447.
42. A. Martins, M. S. Santos, C. Dias, P. Serra, V. Cachatra, J. Pais, J. Caio, V. H. Teixeira, M. Machuqueiro, M. S. Silva, A. Pelerito, J. Justino, M. Goulart, F. V. Silva, A. P. Rauter, Tuning bioactivity of new tensioactive deoxy glycosides with structure: antibacterial activity vs. selective cholinesterase inhibition rationalized by molecular docking, Eur. J. Org. Chem. 2013, 8, 1448-1459.
43. S. Silva, E. M. Sanchez-Fernandez, C. O. Mellet, A. Tatibouet, A. P. Rauter, P. Rollin, N-Thiocarbonyl imino sugars: synthesis and evaluation of castanospermine analogues bearing oxazole-2(3H)-thione moieties, Eur. J. Org. Chem. 2013, 7941-7951.
44. M. A. Brimble, D. S. Black, R. Hartshorn, A. P. Rauter, C.-K. Sha, L. K. Sydnes, Rules for abbreviation of protecting groups, Pure Appl. Chem. 2013, 85(1), 307-313.
2012
45. A. P. Rauter, C. Dias, A. Martins, I. Branco, N. R. Neng, J. M. Nogueira, M. Goulart, F. V.M. Silva, J. Justino, C. Trevitt, J. P. Waltho, Non-toxic Salviasclareoides Brot. extracts as a source of functional food ingredients: phenolic profile, antioxidant activity and prion binding properties, Food Chem. 2012, 132(4), 1930-1935.
46. L. Custodio, T. Justo, L. Silvestre, A. Barradas, C. V. Duarte, H. Pereira, L. Barreira, A. P. Rauter, F. Alberício, J. Varela, Microalgae of different phyla display antioxidant, metal chelating and acetylcholinesterase inhibitory activities, Food Chem. 2012, 131(1), 134-140, DOI: 10.1016/j.foodchem.2011.08.047
47. N. M. Xavier, A. P. Rauter, Environmentally friendly approaches to the synthesis of new antibiotics from sugars, Pure Appl. Chem. 2012, 84(3), 803-816.
47. N. M. Xavier, A. P. Rauter, Environmentally friendly approaches to the synthesis of new antibiotics from sugars, Pure Appl. Chem. 2012, 84(3), 803-816.
48. J. P. Coelho, A. F. Cristino, P. G. Matos, A. P. Rauter, B. P. Nobre, R. L. Mendes, J. G. Barroso, A. Mainar, J. S. Urieta, J. M. N. A. Fareleira, H. Sovova, A. F. Palavra, Extraction of Volatile Oil from Aromatic Plants with Supercritical Carbon Dioxide: Experiments and Modeling, Molecules 2012, 17(9), 10550-10573, DOI: 10.3390/molecules170910550
49. J. A. Figueiredo, M. I. Ismael, J. M. Pinheiro, A. M. S. Silva, J. Justino, F. M. S. Silva, M. Goulart, D. Mira, M. E. M. Araujo, R. Campoy, A. P. Rauter, Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C-C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors, Carbohydr. Res. 2012, 347(1), 47-54.
50. L. Custodio, A. C. Ferreira, H. Pereira, L. Silvestre, C. Vizetto-Duarte, L. Barreira, A. P. Rauter, F. Albericio, J. Varela, The marine halophytes Carpobrotusedulis L. and Arthrocnemummacrostachyum L. are potential sources of nutritionally important PUFAs and metabolites with antioxidant, metal chelating and anticholinesterase inhibitory activities, Botanica Marina 2012, 55(3), 281-288. DOI: 10.1515/bot-2012-0098
51. L. B. Roseiro, A. P. Rauter, M. L. M. Serralheiro, Polyphenols as acetylcholinesterase inhibitors, Nutrition & Aging, 2012, 1(2), 99-111. DOI 10.3233/NUA-2012-0006
2011
52. L. Amorim, F. Marcelo, C. Rousseau, L. Nieto, J. Jiménez-Barbero, J. Marrot, A. P. Rauter, M. Sollogoub, M. Bols, Y. Blériot, Direct experimental evidence for the high chemical reactivity of alpha- and beta-xylopyranosides adopting a 2,5B conformation in glycosyl transfer, Chem. Eur. J. 2011, 17, 7345 – 7356.
53. O. Pinto, J. Sardinha, P. D. Vaz, F. Piedade, M. J. Calhorda, R. Abramovitch, N. Nazareth, M. Pinto, M. S. J. Nascimento, A. P. Rauter, Synthesis of tetrahydronaphthalene lignan esters by intramolecular cyclization of ethyl p-azidophenyl 2-phenylalkanoates and evaluation of the growth inhibition of human tumor cell lines, J. Med. Chem. 2011, 54, 3175–3187.
54. A. C. Araújo, A. P. Rauter, F. Nicotra, C. Airoldi, B. Costa, L. Cipolla, Sugar-based enantiomeric and conformationally constrained pyrrolo[2,1-c][1,4]-benzodiazepines as potential GABAA ligands, J. Med. Chem., 2011, 54, 1266–1275.
55. N. M. Xavier, M. Goulart, A. Neves, J. Justino, S. Chambert, A. P. Rauter, Yves Queneau, Synthesis of Sugars Embodying Conjugated Carbonyl Systems and Related Triazole Derivatives from Carboxymethyl Glycoside Lactones. Evaluation of their Antimicrobial Activity and Toxicity, Bioorg. Med. Chem., 2011, 19(2), 926-938.
56. A. Tatibouet, Ana-Catarina Simao, Sandrina Silva, Amelia P. Rauter, Patrick Rollin, Controlled Garegg Conditions for Selective Iodination on Pyranose Templates, Eur. J. Org. Chem., 2011, 2011(12), 2286-2292.
57. N. M. Xavier, Y. Queneau, A. P. Rauter, Exploitation of Furanoid 5-Azido-3-C-Branched-Chain Sugars as Precursors Towards Highly Functionalized Nitrogen-Containing Sugars, Eur. J. Org. Chem., 2011, 2011(4), 713-720.
58. A. M. F. Palavra, J. P. Coelho, J.G. Barroso, A. P. Rauter, J. M. N. A. Fareleira, A. Mainar, J. S. Urieta, B. P. Nobre, L. Gouveia, R.L. Mendes, J. M. S. Cabral, J. M. Novais, Supercritical Carbon Dioxide Extraction of Bioactive Compounds from Fluids, J. Supercrit. Fluids, 2011, 60, 21-27.
59. R. G. Santos, A. R. Jesus, J. M. Caio, A. P. Rauter, Fries-type Reactions for the C-Glycosylation of Phenols, Curr. Org. Chem., 2011, 15(1), 128-148.
60. S. D. Lucas, H. Fischer, A. Alker, A. P. Rauter, H. P. Wessel; Libraries on Oxetane delta-Amino Acid Scaffolds: Syntheses and Evaluation of Physicochemical and Metabolic Properties, J. Carbohydr. Chem., 2011, 30, 498-548.
2010
61. N. M. Xavier, A. P. Rauter, Y. Queneau, Carbohydrate-based lactones: synthesis and applications. Top. Curr. Chem.,2010, 295, 19-62.
62. J. Salta, A. Martins, R. G. Santos, N. R. Neng, J. M.F. Nogueira, J. Justino, A. P. Rauter, Phenolic composition and antioxidant activity of Rocha pear and other pear cultivars – A comparative study, J. Functional Foods, 2010, 2, 153-157.
63. A. P. Rauter, N. M. Xavier, S. D. Lucas, M. Santos, Zeolites and other silicon-based promoters in Carbohydrate Chemistry, Adv. Carbohydr. Chem. Biochem. 2010, 63, 29-99.
64. M. T. Cabrita, C. Vale, A. P. Rauter, Halogenated compounds from marine algae, Marine Drugs 2010, 8(8), 2301-2317.
65. P. J. A. Madeira, N. M. Xavier, A. P. Rauter, M. H. Florêncio, Furanose C-C-linked γ-lactones: a combined ESI FTICR MS and semi-empirical calculations study, J. Mass Spectrom. 2010,45(10), 1167-1178.
66. P. J. A. Madeira, A. M. Rosa, N. M. Xavier, A. P. Rauter, M. H. Florêncio, Electrospray ionization mass spectrometric analysis of newly synthesized alpha,beta-unsaturated gamma-lactones fused to sugars, Rapid Commun. Mass Spectrom. 2010, 24(7), 1049-1058.
67. A. P. Rauter, A. Martins, C. Borges, H. Mota-Filipe, R. Pinto, B. Sepodes, J. Justino, Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats, Phytother. Res. 2010, 24, S133-S138 (Top 5, 34 citations, in March1, 2017)
68. A. C. Simão, A. Tatibouet, A. P Rauter, P. Rollin, Selective iodination of vicinal cis-diols on ketopyranose templates, Tetrahedron Lett. 2010, 51(35), 4602-4604.
2009
69. N. M. Xavier, S. D. Lucas, A. P. Rauter. Zeolites as efficient catalysts for key transformations in carbohydrate chemistry, J. Mol. Catal. A: Chem. 2009, 305(1-2), 84–89.
70. F. Marcelo, F. V. M. Silva, M. Goulart, J. Justino, P. Sinay, Y. Bleriot, A. P. Rauter, Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase, Bioorg. Med. Chem. 2009, 17(14), 5106-5116.
71. F. Marcelo, F. V. M. Silva, M. Goulart, J. Justino, P. Sinay, Y. Bleriot, A. P. Rauter, Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase, Bioorg. Med. Chem. 2009, 17(14), 5106-5116.
72. N. M. Xavier, P. J. A. Madeira, M. H. Florêncio, A. P. Rauter, Synthetic approaches to novel thiosugar scaffolds containing α,β-unsaturated carbonyl groups, Eur. J. Org. Chem. 2009, 2009(29), 4983-4991.
73. F. V. M. Silva, A. Martins, J. Salta, N. R. Neng, J. M. F. Nogueira, D. Mira, N. Gaspar, J. Justino, C. Grosso, J. S. Urieta, A. M. S. Palavra, A. P. Rauter, Phytochemical profile and anticholinesterase and antimicrobial activities of supercritical versus conventional extracts ofSatureja montana, J. Agric. Food Chem. 2009, 57(24), 11557-11563.
74. A.P. Rauter, A. Martins, R. Lopes, J. Ferreira, L. M. Serralheiro, M.-E. Araújo, C. Borges, J. Justino, F. V. Silva, M. Goulart, J. Thomas-Oates, J. A. Rodrigues, E. Edwards, J. P. Noronha, R. Pinto, H. Mota-Filipe, Bioactivity studies and chemical profile of the antidiabetic plant Genista tenera, J. Ethnopharmacol. 2009, 122(2), 384–393.
75. F. Marcelo, R. Abou-Jneid, M. Sollogoub, J. Marrot, A. P. Rauter, Y. Blériot, Total synthesis of the epimer at C-6' of the Miharamycin B framework,SYNLETT, 2009, 8, 1269-1272.
76. S. D. Lucas, A. P. Rauter, J. Schneider, H.-P. Wessel, Synthesis of 3-fluoro-oxetane δ-amino acids, J. Carbohydr. Chem. 2009, 28(7-8), 431–446.
2008
77. Silva, B. Sylla, F. Suzenet, A. Tatibouet, A. P. Rauter, P. Rollin, Oxazolinethiones and oxazolidinethiones for the first copper-catalyzed desulfurative cross-coupling reaction and first Sonogashira applications, Org. Lett.2008, 10(5), 853-856.
78. F. Marcelo, J. Jimenez-Barbero, J. Marrot, A. P. Rauter, P. Sinaÿ, Y. Blériot, Stereochemical assignment and first synthesis of the core of Miharamycin antibiotics, Chem. Eur. J., 2008, 14(32), 10066-10073.
79. A. Ramos, S. Coesel, A. Marques, M. Rodrigues, A. Baumgartner, J. Noronha, A. Rauter, B. Brenig, J. Varela, Isolation and characterization of a stress-inducible Dunaliella salina Lcy-beta gene encoding a functional lycopene beta-cyclase, Appl. Microbiol. Biotech.2008, 79(5), 819-828.
80. F. V. M. Silva, M. Goulart, J. Justino, A. Neves, F. Santos, J. Caio, S. Lucas, A. Newton, D. Sacoto, E. Barbosa, M. S. Santos, A.P. Rauter, Alkyl deoxy-arabino-hexopyranosides: Synthesis, surface properties, and biological activities, Bioorg. Med. Chem. 2008, 16(7), 4083-4092.
81. N. M. Xavier, S. Silva, P. J. A. Madeira, M. H. Florêncio, F. V. M. Silva, J. Justino, J. Thiem, A. P. Rauter, Synthesis and biological evaluation of sugars containing α,β-unsaturated γ-lactones, Eur. J. Org. Chem. 2008, 2008(36), 6134-6143.
82. S. Silva, S. Tardy, S. Routier, F. Suzenet, A. Tatibouet, A. P. Rauter, P. Rollin, 1,3-Oxazoline- and 1,3-Oxazolidine-2-thiones as Substrates in direct modified Stille and Suzuki cross-coupling, Tetrahedron Lett. 2008, 49(39), 5583-5586.
83. J. Sardinha, A. P. Rauter, M. Sollogoub, First synthesis of 5-fluoro-(+)-MK7607, its 1-epimer and 6-deoxy derivative, Tetrahedron Lett. 2008, 49(38), 5548-5550.
84. S. Silva, A. C. Simão, A. Tatibouët, P. Rollin, A. P. Rauter, HSCN condensation with ulosides: preferred formation of carbohydrate-fused hemiaminals of the 4-hydroxy-1,3-oxazolidine-2-thione type, Tetrahedron Lett. 2008, 49, 682-686.
85. N. M. Xavier, A. P. Rauter, Sugars containing α,β-unsaturated carbonyl systems: synthesis and their usefulness as scaffolds in Carbohydrate Chemistry, Carbohydr. Res. 2008, 343(10-11), 1523-1539.
86. S. D. Lucas, A. P. Rauter, H. P. Wessel, Synthesis of 3-methoxyoxetane δ-amino acids with D-lyxo, D-ribo, and D-arabino configurations, J. Carbohydr. Chem. 2008, 27(3), 172-187.
2007
87. N. M. Xavier, A. P. Rauter, Easy and stereoselective approach to alpha,beta-unsaturated gamma-lactones fused to pyranoses from furanose scaffolds, Org. Lett.2007, 9(17), 3339-3341.
88. A. P. Rauter, T. Almeida, N. M. Xavier, F. Siopa, A. I. Vicente, S. D. Lucas, J. P. Marques, F. Ramôa Ribeiro, M. Guisnet, M. J. Ferreira, Acid zeolites as efficient catalysts for O- and S-glycosylation, J. Mol. Catal. A: Chem.2007, 275, 206–213.
89. A. P. Rauter, I. Branco, R. G. Lopes, J. Justino, F. V. M. Silva, J. P. Noronha, E. J. Cabrita, I. Brouard, J. Bermejo, A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides, Fitoterapia 2007, 78(7-8), 474-481.
90. J. Sardinha, S. Guieu, A. Deleuze, M. C. Fernández-Alonso, A. P. Rauter, P. Sinaÿ, J. Marrot, J. Jiménez-Barbero, M. Sollogoub, gem-Difluoro-carbasugars, the cases of mannopyranose and galactopyranose, Carbohydr. Res. 2007, 342(12-13), 1689-1703.
91. A. P. Rauter, R. G. Lopes, A. Martins, C-Glycosylflavonoids: Identification, bioactivity, and synthesis,Nat. Prod. Commun. 2007, 2(11), 1175-1196.
2006
92. E. Edwards, J. Rodrigues, J. Ferreira, D. Goodall, A. Rauter, J. Justino, J. Thomas-Oates, Capillary electrophoresis-mass spectrometry characterisation of secondary metabolites from the antihyperglycaemic plant Genista tenera, Electrophoresis 2006, 27(11), 2164-2170.
93. A.P. Rauter, T. Almeida, A. I. Vicente, V. Ribeiro, J. C. Bordado, J. P. Marques, F. Ramôa-Ribeiro, M. J. Ferreira, C. Oliveira, M. Guisnet, Reactions of N-, S- and O-nucleophiles with 3,4,6-tri-O-benzyl-D-glucal mediated by triphenylphosphane hydrobromide versus those with HY zeolite, Eur. J. Org. Chem. 2006, 2006(10), 2429-2439.
94. N. Leconte, S. Silva, A. Tatibouët, A. P. Rauter, P. Rollin, Aromatic or chiral heterocycle - Balance between 1,3-oxazoline-2-thione and 1,3-oxazolidine-2-thione, SYNLETT 2006, 2, 301-305.
96. S. D. Lucas, H. Iding, A. Alker, H. P. Wessel, A. P. Rauter, Oxetane δ-amino acids: Chemoenzymatic synthesis of 2,4-anhydro-5-N-(t-butoxycarbonyl)amino-d-lyxonic acid, J. Carbohydr. Chem. 2006, 25(2-3), 187-196.
2005
97. A. P. Rauter, A. Martins, C. Borges, J. Ferreira, J. Justino, M.-R. Bronze, A. V. Coelho, Y. H. Choi, R. Verpoorte, Liquid chromatography-diode array detection-electrospray ionisation mass spectrometry/nuclear magnetic resonance analyses of the anti-hyperglycemic flavonoid extract of Genista tenera - Structure elucidation of a flavonoid-C-glycoside, J. Chromatogr. A 2005, 1089(1-2), 59-64.
98. J. Justino, A. P. Rauter, T. Canda, R. Wilkins, E. Matthews, Sugar derivatives containing oxiranes and alpha,beta-unsaturated gamma-lactones as potential environmentally friendly insecticides, Pest Manag. Sci. 2005, 61, 985-990
99. A. Martins, M. Wink, A. Tei, M. Brum-Bousquet, F. Tillequin, A. P. Rauter, A phytochemical study of the quinolizidine alkaloids from Genista tenera by gas chromatography-mass spectrometry, Phytochem. Anal. 2005, 16(4), 264-266.
100. A. P. Rauter, M. M. Filipe, C. Prata, J. P. Noronha, M. A. M. Sampayo, J. Justino, J. Bermejo, A new dihydroxysterol from the marine phytoplanktonDiacronema sp., Fitoterapia 2005, 76(5), 433-438.
101. Z.Tostão, J. P. Noronha, E. J. Cabrita, J. Medeiros, J. Justino, J. Bermejo, A. P. Rauter, A novel pentacyclic triterpene fromLeontodon filii,Fitoterapia 2005, 76(2), 173-180.
102. A.P. Rauter, S. Lucas, T. Almeida, D. Sacoto, V. Ribeiro, J. Justino, A. Neves, F. V. M. Silva, M. C. Oliveira, M. J. Ferreira, M.-S. Santos, E. Barbosa, Synthesis, surface active and antimicrobial properties of new alkyl 2,6-dideoxy-L-arabino-hexopyranosides,Carbohydr. Res. 2005, 340(2), 191-201.
103. A.P. Rauter, M. Padilha, J. A. Figueiredo, M. I. Ismael, J. Justino, H. Ferreira, M. J. Ferreira, C. Rajendran, R. Wilkins, P. Vaz, M. J. Calhorda, Bioactive pseudo-C-nucleosides containing azole, thiazolidinone, and tetrazole rings, J. Carbohydr. Chem. 2005, 24(3), 275-296.
International R&D Book
Chapters (2017-2008)
104. A. M. Matos, R. Nunes, C. Dias, and A. P. Rauter. Cyclic Acetals for Regioselective Protection in Carbohydrate Synthesis: A Comparative Experiment In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, Eds C. A. M. Afonso, N. R. Candeias, D. P. Simão, A. F. Trindade, J. A. S. Coelho, B. Tan, R. Franzén, The Royal Society of Chemistry, Cambridge, 2017, pp 188-193.
105. C. Dias, and A. P. Rauter. Glycal Transformation into Surfactant 2-Deoxy Glycosides In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, Eds C. A. M. Afonso, N. R. Candeias, D. P. Simão, A. F. Trindade, J. A. S. Coelho, B. Tan, R. Franzén, The Royal Society of Chemistry, Cambridge, 2017, pp 247-251.
106. V. Cachatra, A. P. Rauter, Domino reactions Toward Carbohydrtae Frameworks for Applications Across Biology and Medicine, Chapter 4, In: Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience, Ed. Z. Witczak, R. Bielski, Wiley, 2016, pp76-96.
107. C. Dias, A. M. Matos, A. P. Rauter, Chemical approaches toward neurodegenerative disease prevention: the role of coupling sugars to phenolic biomolecular entities. In: Coupling and Decoupling of Diverse Molecular Units in Glycosciences, Eds. Z. Witczak and R. Bielski, Springer Verlag: Germany, 2016 (in press).
108. C. Dias, A. Martins, M. S. Santos, A. P. Rauter, M. Malik; Glycal transformation into 2-deoxy glycosides; In: Carbohydrate Chemistry - Proven Synthetic Methods (Ed. S. Vidal), Vol. 3, CRC Press - Taylor & Francis: Boca Raton, Florida, 2015, pp 57-72.
109. C. Dias, A. P. Rauter. Chapter 8: Carbohydrates and Glycomimetics in Alzheimer’s Disease Therapeutics and Diagnosis, In: Carbohydrates in Drug Design, Edited by J. Jiménez Barbero, The Royal Society of Chemistry, 2015, pp. 180-208.
110. A. R. Jesus, A. P. Rauter, J. Liu; Recent Advances in Enzymatic Synthesis of Heparin; In: Carbohydrate Chemistry – Chemical and Biological Approaches, Vol 39, Eds. A. P. Rauter, T.K. Lindhorst, RSCPublishing: Cambridge, pp. 38-57, 2013.
111. R. G. Soengas, J. M. Otero, A. M. Estévez, A. P. Rauter, V. Cachatra, J. C. Estévez, R. J. Estévez; Na overview of key routes for the transformation of sugars into carbasugars and related compounds; In: Carbohydrate Chemistry – Chemical and Biological Approaches, Vol 38, Eds. A. P. Rauter, T.K. Lindhorst, RSCPublishing: Cambridge, pp. 263-302, 2012.
112. M. M. Andrade, A. P. Rauter; Synthesis of carbohydrate-based artificial siderophores and their biological applications; In:Carbohydrate Chemistry – Chemical and Biological Approaches, Vol 38, Eds. A. P. Rauter, T.K. Lindhorst, RSCPublishing: Cambridge, pp. 398-415, 2012.
113. S. Schwarz, N. M. Xavier, R. Csuk, A. P. Rauter; Triterpene/Steroid Glycoconjugates: Natural Occurrence, Synthesis and Biological Activities; in Carbohydrate Chemistry – Chemical and Biological Approaches, Vol 37, Eds. A. P. Rauter, T. K. Lindhorst, RSCPublishing: Cambridge, pp. 326-366, 2012.
114. J. Sardinha, A. P. Rauter, M. Sollogoub, Y. Bleriot; TIBAL Induced Rearrangement: Synthesis of gem-Difluorocarbagalactose; in Carbohydrate Chemistry: Proven Methods, Vol. 1, Ed. P. Kovac, CRC Press - Taylor & Francis: Boca Raton, Florida, Chapter 14, pp. 129-136, 2011.
115. N. M. Xavier, S. Kopitzki, A. P. Rauter; Pyranose-Fused Butenolides: An Expedient Preparation from Furanose Synthons; in Carbohydrate Chemistry: Proven Methods, Vol. 1, Ed. P. Kovac, CRC Press - Taylor & Francis: Boca Raton, Florida, Chapter 15, pp. 137-158, 2011.
116. L. Cipolla, B. La Ferla, A. P. Rauter, F. Nicotra; Regioselective debenzylation of C-glycosylpropene; in Carbohydrate Chemistry: Proven Methods, Vol. 1, Ed. P. Kovac, CRC Press - Taylor & Francis: Boca Raton, Florida, Chapter 17, pp. 167-174, 2011.
117. A. C. Simão, J. Rousseau, S. Silva, A. P. Rauter, A. Tatibouët, P. Rollin, Thionocarbamates on carbohydrate scaffolds – from synthesis to bioactivity. Em: Specialist Periodical Reports: Carbohydrate Chemistry – Chemical and Biological Approaches, A. P. Rauter, T. Lindhorst, Eds., The Royal Society of Chemisty, Cambridge, Vol. 35, pp. 127-172, 2009.
118. A. P. Rauter, E. Gaspar, J. P. Noronha, A. Escudeiro, Plantas Medicinales Iberoamericanas, M. H. Gupta, Ed., Bogota, Colombia: Convenio Andres Bello, Série de Ciencia y Tecnologia No 158, 2008 (authors of the book content on Portuguese medicinal plants).
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