Research articles

  1. Carmona, B., Marinho, H.S., Lopes Matos, C., Nolasco, S., Soares, H. (2023) Tubulin post-translational modifications: the elusive roles of acetylation. Biology 12(4), 561; doi: 10.3390/biology12040561.
  2. Carvalheiro, M., Ferreira-Silva, M., Holovanchuk, D., Marinho, H. S., Moreira, J. N., Soares, H., Corvo, M. L., Cruz, M. E. M. (2022) Antagonist G-targeted liposomes for improved delivery of anticancer drugs in small cell lung carcinoma. International Journal of Pharmaceutics, 612:121380. doi: 10.1016/j.ijpharm.2021.121380
  3. Ferreira-Silva, M.; Faria-Silva, C.; Carvalheiro, M.C.; Simões, S.; Marinho, H.S.; Marcelino, P.; Campos, M.C.; Metselaar, J.M.; Fernandes, E.; Baptista, P.V.; Fernandes, A.R.; Corvo, M.L. Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment. Pharmaceutics 202214, 104. doi: 10.3390/pharmaceutics14010104
  4. Bento-Oliveira, A., Santos, F.C., Marquês, J.T., Paulo, P.M.R., Korte, T., Herrmann, A., Marinho, H.S., de Almeida, R.F.M. (2020) Yeast Sphingolipid-Enriched Domains and Membrane Compartments in the Absence of Mannyldiinositolphosphorylceramide. Biomolecules10, 871. doi:10.3390/biom10060871 .
  5. Khmelinskaia A, Marquês JMT, Bastos AEP, Antunes CAC, Bento-Oliveira A, Scolari S, Lobo GMDS, Malhó R, Herrmann A, Marinho H.S., de Almeida RFM. (2020)Liquid-Ordered Phase Formation by Mammalian and Yeast Sterols: A Common Feature With Organizational Differences. Front Cell Dev Biol. 8:337. doi: 10.3389/fcell.2020.00337.
  6. Santos, T., Marinho, H.S., Cyrne, L. (2019) Inositol transporters regulation by hydrogen peroxide in S. cerevisiae. Arch. Microbiol. 201, 123-134. DOI: 10.1007/s00203-018-1584-1.
  7. Marinho, H.S., Marcelino, P., Soares, H., Corvo, M.L. (2018) Gene silencing using siRNA for preventing liver ischaemia-reperfusion injury. Curr. Pharm. Des. 24, 1-9.doi: 10.2174/1381612824666180807124356. [pdf]
  8. Marquês, J. T., Marinho, H.S., de Almeida, R.F.M. (2018) Sphingolipid hydroxylation in mammals, yeast and plants – an integrated view. Prog. Lipid Res. 71, 18-42. doi: 10.1016/j.plipres.2018.05.001.
  9. Marcelino, P., Marinho, H.S., Campos, M.C., Neves, A.R., Real, C., Fontes, F.S., Carvalho, A., Feio, G., Martins, M.B.F., Corvo, M.L. (2017) Therapeutic activity of superoxide dismutase-containing enzymosomes on rat liver ischaemia-reperfusion injury followed by magnetic resonance microscopy. European J. Pharmacol. Sci. 109, 464-471. doi:10.1016/j.ejps.2017.09.008.
  10. Camelo, C., Vilas-Boas, F., Cepeda, A. P., Real, C., Barros-Martins, J., Pinto, F., Soares, H., Marinho, H.S., Cyrne, L. (2017) Opi1p translocation to the nucleus is regulated by hydrogen peroxide in Saccharomyces cerevisiae.  Yeast, 34, 383-395. doi:10.1002/yea.3240
  11. Santos, F.C., Fernandes, A.S., Antunes, C.A.C., Moreira, F. P., Videira, A., Marinho, H.S., de Almeida, R.F.M. (2017) Reorganization of plasma membrane lipid domains during conidial germination. Biochim. Biophys. Acta - Molecular and Cell Biology of Lipids 1862, 156-166. doi: 10.1016/j.bbalip.2016.10.011
  12. Marquês, J.T., Cordeiro, A.M., Viana A.S., Herrmann, A., Marinho, H.S., de Almeida, R.F. (2015) Formation and properties of membrane ordered domains by phytoceramide: role of sphingoid base hydroxylation. Langmuir, 31, 9410−9421 doi: 10.1021/acs.langmuir.5b02550
  13. Corvo, M.L., Marinho, H.S., Marcelino, P. Lopes, R., Vale, C.A., Marques, C., Martins L.C.D., Laverman, P., Storm, G., Martins, M.B.F. (2015) Superoxide dismutase enzymosomes: carrier capacity optimization, in vivo behaviour and therapeutic activity. Pharm. Res. 32, 91-102. doi: 10.1007/s11095-014-1447-7.
  14. Marinho H.S., Real, C., Cyrne, L., Soares, H., Antunes, F. (2014) Hydrogen peroxide sensing, signaling and transcription factors regulation. Redox Biol. 2, 535-562. doi: 10.1016/j.redox.2014.02.006. ISI highly cited paper (Top 1% in Biology and Biochemistry)
  15. Soares, H., Marinho H.S., Real, C., Antunes, F. (2014) Cellular polarity in aging: role of redox regulation and nutrition. Genes Nutr., 9, 371. doi: 10.1007/s12263-013-0371-5. Chosen as a key scientific article by Global Medical Discovery.
  16. Martins, M.B.F., Corvo, M.L., Marcelino, P., Marinho, H.S., Feio, G., Carvalho, A. (2014) New long circulating magnetoliposomes as contrast agents for detection of ischemia-reperfusion injuries by MRI.  Nanomed.-Nanotechnol. Biol. Med.10, 207-214. doi:10.1016/j.nano.2013.06.008.
  17. Oliveira-Marques, V., Silva, T., Cunha, F., Covas, G., Marinho, H.S., Antunes, F., Cyrne, L. (2013) A quantitative study of the cell-type specific modulation of c-Rel by hydrogen peroxide and TNF-α. Redox Biology, 1, 347-352. doi:10.1016/j.redox.2013.05.004.
  18. Covas, G., Marinho, H.S., Cyrne, L., Antunes, F. (2013) Activation of Nrf2 by H2O2: de novo synthesis versus nuclear translocation. Methods Enzymol. 528, 157-171. doi:10.1016/B978-0-12-405881-1.00009-4.[pdf]
  19. Cyrne, L., Oliveira-Marques, V., Marinho, H.S., Antunes, F. (2013) H2O2 in the induction of NF-κB-dependent selective gene expression. Methods Enzymol. 528, 173-188. doi:10.1016/B978-0-12-405881-1.00010-0. [pdf]
  20. Marinho, H.S., Cyrne, L., Cadenas, E., Antunes, F. (2013) H2O2 delivery to cells: steady-state versus bolus addition. Methods Enzymol. 526, 159-176. doi:10.1016/B978-0-12-405883-5.00010-7. [pdf]
  21. Marinho, H.S., Cyrne, L., Cadenas E., Antunes, F. (2013) The cellular steady-state of H2O2: latency concepts and gradients. Methods Enzymol. 527, 3-19. doi:10.1016/B978-0-12-405882-8.00001-5. [pdf]
  22. Pedroso, N., Gomes-Alves, P., Marinho, H.S., Brito, V.B., Boada, C., Antunes, F., Herrero, E., Penque, D., Cyrne, L. (2012) The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae. Free Radical Res. 46, 1267-1279. doi:10.3109/10715762.2012.704997.
  23. Bastos, A.E.P., Marinho, H.S., Cordeiro, A.M., Soure, A.M., de Almeida, R.F.M.(2012) Biophysical properties of ergosterol-enriched lipid rafts in yeast and tools for their study: characterization of ergosterol/phosphatidylcholine membranes with three fluorescent membrane probes. Chem. Phys.  Lipids 165, 577–588. doi:10.1016/j.chemphyslip.2012.06.002.
  24. Matias, A., Marinho, H.S., Cyrne, L., Herrero, E., Antunes, F. (2011) Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 515, 107-111. doi:10.1016/
  25. Aresta-Branco, F., Cordeiro, A.M., Marinho, H.S., Cyrne, L., Antunes, F., de Almeida, R.F.M. (2011) Gel domains in the plasma membrane of Saccharomyces cerevisiae: highly ordered, ergosterol-free, sphingolipid-enriched lipid rafts. J. Biol. Chem.,286, 5043-5054. doi:10.1074/jbc.M110.154435..
  26. Cyrne, L., Antunes, F., Sousa-Lopes, A., Diaz-Bérrio, J., Marinho, H.S. (2010) Glyceraldehyde-3-phosphate dehydrogenase is largely unresponsive to low regulatory levels of hydrogen peroxide in Saccharomyces cerevisiae. BMC Biochemistry 11, 49. doi:10.1186/1471-2091-11-49.
  27. Oliveira-Marques, V., Marinho, H.S., Cyrne, L. & Antunes, F. (2009) Role of hydrogen peroxide in NF-kB activation: from inducer to modulator. Antioxid. Redox Signal., 11, 2223-2243. doi:10.1089/ARS.2009.2601 [abstract][pdf]
  28. Oliveira-Marques, V., Marinho, H.S., Cyrne, L. & Antunes, F. (2009) Modulation of NF-kB-dependent gene expression by H2O2: a major role for a simple chemical process in a complex biological response. Antioxid. Redox Signal., 11, 2043-2053.[abstract][pdf]
  29. Pedroso, N., Matias, A.C., Cyrne, L., Antunes, F., Borges, C., Malhó, R., de Almeida, R.F.M., Herrero, E. & Marinho, H.S. (2009) Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae. Free Radic. Biol. Med. 46, 289-298.[abstract][pdf]
  30. Folmer, V., Pedroso, N., Matias, A.C., Lopes, S.C.D.N., Antunes, F., Cyrne, L. & Marinho, H.S. (2008) H2O2 induces rapid biophysical and permeability changes in the plasma membrane of Saccharomyces cerevisiae. Biochim. Biophys. Acta - Biomembranes,1778, 1141-1147.[abstract][pdf]
  31. Matias, A.C., Pedroso, N., Teodoro, N., Marinho, H.S., Antunes, F., Nogueira, J.M., Herrero, E., & Cyrne, L. (2007) Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. Free Radic. Biol. Med., 43, 1458-65.[abstract][pdf]
  32. Oliveira-Marques, V., Cyrne, L., Marinho, H.S., Antunes, F. (2007) A quantitative study of NF-kB activation by H2O2: relevance in inflammation and synergy with TNF-alfa. J. Immunol. 178, 3893-3902. [abstract][pdf]
  33. Sousa-Lopes, A., Antunes, F., Cyrne, L., Marinho, H.S. (2004) Decreased cellular permeability to H2O2 protects Saccharomyces cerevisiae cells in stationary phase against oxidative stress. FEBS Lett. 578, 152-156. [abstract] [pdf]
  34. Branco, M.R., Marinho, H.S., Cyrne, L., Antunes, F. (2004) Decrease of H2O2 plasma membrane permeability during adaptation to H2O2 in Saccharomyces cerevisiae. J. Biol. Chem., 279, 6501-6506. [abstract] [pdf]
  35. Antunes, F., Marinho, H.S., Barreto, M.C., Pavão, M.L., Pinto, R.E. (2003) Diagnosis of enzyme inhibition based on the degree of inhibition. Biochim. Biophys. Acta - General Subjects, 1624, 11-20. [abstract] [pdf][Supplementary Information]
  36. Cyrne, L., Martins, L., Fernandes, L., Marinho, H.S. (2003) Regulation of antioxidant enzymes gene expression in the yeast Saccharomyces cerevisiae during stationary phase. Free Radic. Biol. Med., 34, 385-393. [abstract] [pdf]
  37. Boon, P.J.M., Marinho, H.S., Oosting, R., Mulder, G.J. (1999) The identification of glutathione conjugates of 4-hydroxy-trans-2,3-nonenal in the rat in vivo, the isolated perfused liver and erythrocytes. Toxicol. Appl. Pharmacol.,159, 214-223. [abstract][pdf]
  38. Marinho, H.S., Baptista, M., Pinto, R.E. (1997) Glutathione metabolism in hepatomous liver of rats treated with diethylnitrosamine. Biochim. Biophys. Acta - Molecular Basis of Disease, 1360, 157-168. [abstract][pdf]
  39. Marinho, H.S., Antunes, F., Pinto, R.E. (1997) Role of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in the reduction of lysophospholipid hydroperoxides. Free Radic. Biol. Med., 22, 871-883.[abstract] [pdf]
  40. Antunes, F., Salvador, A., Marinho, H.S., Alves, R., Pinto, R.E. (1996) Lipid peroxidation in inner mitochondrial membranes. I. A new integrative kinetic model. Free Radic. Biol. Med., 21, 917-943. [abstract][pdf]

 Other articles

 Book Chapters

  1. Antunes, F., Soares, H., Marinho, H.S. (2020) Oxigénio: da evolução dos seres vivos à medicina redox, in Os Elementos em Ciências - uma viagem pela Tabela Periódica (Mourato, A., Carvalho, A.P., Martins, F., Pamplona, M.T. ed.), pp. 51-52, Edições Ciências ULisboa. ISBN 978-972-9348-21-1 (paperback); 978-972-9348-22-8 (e-book).
  2. Praça, F.S., Marinho, H.S., Martins, M.B.F., Gaspar, R.S., Corvo, M.L., Medina, W. (2017) Current aspects of breast cancer therapy and diagnosis based on a nanocarrier approach, in Nanostructures for Cancer Therapy (Alexandru Mihai Grumezescu and Anton Ficai, ed.) Chapter 27, pp.749-774. Elsevier. doi: 10.1016/B978-0-323-46144-3.00027-1
  3. Gomes, A.Q., Real, C., Antunes, F., Marinho, H.S., Nolasco, S. and Soares, H. (2017). Non-coding RNAs as critical players in regulatory accuracy, redox signaling and immune cell functions. In Current Developments in Biotechnology and Bioengineering, Book 9: Biotechnology in Human and Animal Health, (Vanete Thomaz-Soccol, Rodrigo R. Resende, Ashok Pandey, eds.), Chapter 10, pp.215–284, Elsevier. doi: 10.1016/b978-0-444-63660-7.00010-3
  4. Corvo, M.L., Marinho, H.S., Martins, M.B.F. (2016) Nanomedicines as a strategy for the therapeutic use of superoxide dismutases, in Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits. (Nancy H. Phillips, ed.), Chapter 4, pp.135-170. NY: Nova Publishers.
  5. Marinho, H.S., Antunes F. (2015) Metabolism of superoxide radical and hydrogen peroxide in mitochondria in Mitochondria in Liver Disease (Derick Han and Neil Kaplowitz eds) Chapter 1, pp. 1- 28. Boca Raton: CRC Press.
  6. Oliveira-Marques, V., Marinho, H.S., Cyrne, L., Antunes, F., (2007) Steady-state titration with H2O2: Regulation of Plasma membrane and of NF-kB activation by H2O2. in Oxidative Stress: Clinical and Biomedical Implications, (Bashir Matata & Maqsood M. Elahi, ed.), pp. 59-67, Nova Publishers.
  7. Marinho, H.S., Pinto, R.E. (1997) Alguns aspectos da Química Orgânica com interesse em Bioquímica, In Bioquímica (Halpern, M.J. ed.), pp. 25-42, Lisboa: Lidel, edições técnicas.
  8. Pinto, R.E., Marinho, H.S. (1997) Breve História da Bioquímica, In Bioquímica (Halpern, M.J. ed.), pp. 13-23, Lisboa: Lidel, edições técnicas.