Research articles
- Carmona, B., Marinho, H.S., Lopes Matos, C., Nolasco, S., Soares, H. (2023) Tubulin post-translational modifications: the elusive roles of acetylation. Biology 12(4), 561; doi: 10.3390/biology12040561.
- Carvalheiro, M., Ferreira-Silva, M., Holovanchuk, D., Marinho, H. S., Moreira, J. N., Soares, H., Corvo, M. L., Cruz, M. E. M. (2022) Antagonist G-targeted liposomes for improved delivery of anticancer drugs in small cell lung carcinoma. International Journal of Pharmaceutics, 612:121380. doi: 10.1016/j.ijpharm.2021.121380
- Ferreira-Silva, M.; Faria-Silva, C.; Carvalheiro, M.C.; Simões, S.; Marinho, H.S.; Marcelino, P.; Campos, M.C.; Metselaar, J.M.; Fernandes, E.; Baptista, P.V.; Fernandes, A.R.; Corvo, M.L. Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment. Pharmaceutics 2022, 14, 104. doi: 10.3390/pharmaceutics14010104
- Bento-Oliveira, A., Santos, F.C., Marquês, J.T., Paulo, P.M.R., Korte, T., Herrmann, A., Marinho, H.S., de Almeida, R.F.M. (2020) Yeast Sphingolipid-Enriched Domains and Membrane Compartments in the Absence of Mannyldiinositolphosphorylceramide. Biomolecules, 10, 871. doi:10.3390/biom10060871 .
- Khmelinskaia A, Marquês JMT, Bastos AEP, Antunes CAC, Bento-Oliveira A, Scolari S, Lobo GMDS, Malhó R, Herrmann A, Marinho H.S., de Almeida RFM. (2020)Liquid-Ordered Phase Formation by Mammalian and Yeast Sterols: A Common Feature With Organizational Differences. Front Cell Dev Biol. 8:337. doi: 10.3389/fcell.2020.00337.
- Santos, T., Marinho, H.S., Cyrne, L. (2019) Inositol transporters regulation by hydrogen peroxide in S. cerevisiae. Arch. Microbiol. 201, 123-134. DOI: 10.1007/s00203-018-1584-1.
- Marinho, H.S., Marcelino, P., Soares, H., Corvo, M.L. (2018) Gene silencing using siRNA for preventing liver ischaemia-reperfusion injury. Curr. Pharm. Des. 24, 1-9.doi: 10.2174/1381612824666180807124356. [
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- Marquês, J. T., Marinho, H.S., de Almeida, R.F.M. (2018) Sphingolipid hydroxylation in mammals, yeast and plants – an integrated view. Prog. Lipid Res. 71, 18-42. doi: 10.1016/j.plipres.2018.05.001.
- Marcelino, P., Marinho, H.S., Campos, M.C., Neves, A.R., Real, C., Fontes, F.S., Carvalho, A., Feio, G., Martins, M.B.F., Corvo, M.L. (2017) Therapeutic activity of superoxide dismutase-containing enzymosomes on rat liver ischaemia-reperfusion injury followed by magnetic resonance microscopy. European J. Pharmacol. Sci. 109, 464-471. doi:10.1016/j.ejps.2017.09.008.
- Camelo, C., Vilas-Boas, F., Cepeda, A. P., Real, C., Barros-Martins, J., Pinto, F., Soares, H., Marinho, H.S., Cyrne, L. (2017) Opi1p translocation to the nucleus is regulated by hydrogen peroxide in Saccharomyces cerevisiae. Yeast, 34, 383-395. doi:10.1002/yea.3240
- Santos, F.C., Fernandes, A.S., Antunes, C.A.C., Moreira, F. P., Videira, A., Marinho, H.S., de Almeida, R.F.M. (2017) Reorganization of plasma membrane lipid domains during conidial germination. Biochim. Biophys. Acta - Molecular and Cell Biology of Lipids 1862, 156-166. doi: 10.1016/j.bbalip.2016.10.011
- Marquês, J.T., Cordeiro, A.M., Viana A.S., Herrmann, A., Marinho, H.S., de Almeida, R.F. (2015) Formation and properties of membrane ordered domains by phytoceramide: role of sphingoid base hydroxylation. Langmuir, 31, 9410−9421 doi: 10.1021/acs.langmuir.5b02550
- Corvo, M.L., Marinho, H.S., Marcelino, P. Lopes, R., Vale, C.A., Marques, C., Martins L.C.D., Laverman, P., Storm, G., Martins, M.B.F. (2015) Superoxide dismutase enzymosomes: carrier capacity optimization, in vivo behaviour and therapeutic activity. Pharm. Res. 32, 91-102. doi: 10.1007/s11095-014-1447-7.
- Marinho H.S., Real, C., Cyrne, L., Soares, H., Antunes, F. (2014) Hydrogen peroxide sensing, signaling and transcription factors regulation. Redox Biol. 2, 535-562. doi: 10.1016/j.redox.2014.02.006. ISI highly cited paper (Top 1% in Biology and Biochemistry)
- Soares, H., Marinho H.S., Real, C., Antunes, F. (2014) Cellular polarity in aging: role of redox regulation and nutrition. Genes Nutr., 9, 371. doi: 10.1007/s12263-013-0371-5. Chosen as a key scientific article by Global Medical Discovery.
- Martins, M.B.F., Corvo, M.L., Marcelino, P., Marinho, H.S., Feio, G., Carvalho, A. (2014) New long circulating magnetoliposomes as contrast agents for detection of ischemia-reperfusion injuries by MRI. Nanomed.-Nanotechnol. Biol. Med.10, 207-214. doi:10.1016/j.nano.2013.06.008.
- Oliveira-Marques, V., Silva, T., Cunha, F., Covas, G., Marinho, H.S., Antunes, F., Cyrne, L. (2013) A quantitative study of the cell-type specific modulation of c-Rel by hydrogen peroxide and TNF-α. Redox Biology, 1, 347-352. doi:10.1016/j.redox.2013.05.004.
- Covas, G., Marinho, H.S., Cyrne, L., Antunes, F. (2013) Activation of Nrf2 by H2O2: de novo synthesis versus nuclear translocation. Methods Enzymol. 528, 157-171. doi:10.1016/B978-0-12-405881-1.00009-4.[
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- Cyrne, L., Oliveira-Marques, V., Marinho, H.S., Antunes, F. (2013) H2O2 in the induction of NF-κB-dependent selective gene expression. Methods Enzymol. 528, 173-188. doi:10.1016/B978-0-12-405881-1.00010-0. [
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- Marinho, H.S., Cyrne, L., Cadenas, E., Antunes, F. (2013) H2O2 delivery to cells: steady-state versus bolus addition. Methods Enzymol. 526, 159-176. doi:10.1016/B978-0-12-405883-5.00010-7. [
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- Marinho, H.S., Cyrne, L., Cadenas E., Antunes, F. (2013) The cellular steady-state of H2O2: latency concepts and gradients. Methods Enzymol. 527, 3-19. doi:10.1016/B978-0-12-405882-8.00001-5. [
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- Pedroso, N., Gomes-Alves, P., Marinho, H.S., Brito, V.B., Boada, C., Antunes, F., Herrero, E., Penque, D., Cyrne, L. (2012) The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae. Free Radical Res. 46, 1267-1279. doi:10.3109/10715762.2012.704997.
- Bastos, A.E.P., Marinho, H.S., Cordeiro, A.M., Soure, A.M., de Almeida, R.F.M.(2012) Biophysical properties of ergosterol-enriched lipid rafts in yeast and tools for their study: characterization of ergosterol/phosphatidylcholine membranes with three fluorescent membrane probes. Chem. Phys. Lipids 165, 577–588. doi:10.1016/j.chemphyslip.2012.06.002.
- Matias, A., Marinho, H.S., Cyrne, L., Herrero, E., Antunes, F. (2011) Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 515, 107-111. doi:10.1016/j.abb.2011.08.009
- Aresta-Branco, F., Cordeiro, A.M., Marinho, H.S., Cyrne, L., Antunes, F., de Almeida, R.F.M. (2011) Gel domains in the plasma membrane of Saccharomyces cerevisiae: highly ordered, ergosterol-free, sphingolipid-enriched lipid rafts. J. Biol. Chem.,286, 5043-5054. doi:10.1074/jbc.M110.154435.
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- Cyrne, L., Antunes, F., Sousa-Lopes, A., Diaz-Bérrio, J., Marinho, H.S. (2010) Glyceraldehyde-3-phosphate dehydrogenase is largely unresponsive to low regulatory levels of hydrogen peroxide in Saccharomyces cerevisiae. BMC Biochemistry 11, 49. doi:10.1186/1471-2091-11-49.
- Oliveira-Marques, V., Marinho, H.S., Cyrne, L. & Antunes, F. (2009) Role of hydrogen peroxide in NF-kB activation: from inducer to modulator. Antioxid. Redox Signal., 11, 2223-2243. doi:10.1089/ARS.2009.2601 [abstract][
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- Oliveira-Marques, V., Marinho, H.S., Cyrne, L. & Antunes, F. (2009) Modulation of NF-kB-dependent gene expression by H2O2: a major role for a simple chemical process in a complex biological response. Antioxid. Redox Signal., 11, 2043-2053.[abstract][
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- Pedroso, N., Matias, A.C., Cyrne, L., Antunes, F., Borges, C., Malhó, R., de Almeida, R.F.M., Herrero, E. & Marinho, H.S. (2009) Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae. Free Radic. Biol. Med. 46, 289-298.[abstract][
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- Folmer, V., Pedroso, N., Matias, A.C., Lopes, S.C.D.N., Antunes, F., Cyrne, L. & Marinho, H.S. (2008) H2O2 induces rapid biophysical and permeability changes in the plasma membrane of Saccharomyces cerevisiae. Biochim. Biophys. Acta - Biomembranes,1778, 1141-1147.[abstract][
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- Matias, A.C., Pedroso, N., Teodoro, N., Marinho, H.S., Antunes, F., Nogueira, J.M., Herrero, E., & Cyrne, L. (2007) Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. Free Radic. Biol. Med., 43, 1458-65.[abstract][
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- Oliveira-Marques, V., Cyrne, L., Marinho, H.S., Antunes, F. (2007) A quantitative study of NF-kB activation by H2O2: relevance in inflammation and synergy with TNF-alfa. J. Immunol. 178, 3893-3902. [abstract][
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- Sousa-Lopes, A., Antunes, F., Cyrne, L., Marinho, H.S. (2004) Decreased cellular permeability to H2O2 protects Saccharomyces cerevisiae cells in stationary phase against oxidative stress. FEBS Lett. 578, 152-156. [abstract] [
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- Branco, M.R., Marinho, H.S., Cyrne, L., Antunes, F. (2004) Decrease of H2O2 plasma membrane permeability during adaptation to H2O2 in Saccharomyces cerevisiae. J. Biol. Chem., 279, 6501-6506. [abstract] [
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- Antunes, F., Marinho, H.S., Barreto, M.C., Pavão, M.L., Pinto, R.E. (2003) Diagnosis of enzyme inhibition based on the degree of inhibition. Biochim. Biophys. Acta - General Subjects, 1624, 11-20. [abstract] [
][Supplementary Information]
- Cyrne, L., Martins, L., Fernandes, L., Marinho, H.S. (2003) Regulation of antioxidant enzymes gene expression in the yeast Saccharomyces cerevisiae during stationary phase. Free Radic. Biol. Med., 34, 385-393. [abstract] [
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- Boon, P.J.M., Marinho, H.S., Oosting, R., Mulder, G.J. (1999) The identification of glutathione conjugates of 4-hydroxy-trans-2,3-nonenal in the rat in vivo,
the isolated perfused liver and erythrocytes. Toxicol. Appl. Pharmacol.,159, 214-223. [abstract][
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- Marinho, H.S., Baptista, M., Pinto, R.E. (1997) Glutathione metabolism in hepatomous liver of rats treated with diethylnitrosamine. Biochim. Biophys. Acta - Molecular Basis of Disease, 1360, 157-168. [abstract][
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- Marinho, H.S., Antunes, F., Pinto, R.E. (1997) Role of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in the reduction of lysophospholipid hydroperoxides. Free Radic. Biol. Med., 22, 871-883.[abstract] [
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- Antunes, F., Salvador, A., Marinho, H.S., Alves, R., Pinto, R.E. (1996) Lipid peroxidation in inner mitochondrial membranes. I. A new integrative kinetic model. Free Radic. Biol. Med., 21, 917-943. [abstract][
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Other articles
- Araújo, M.E., Cyrne, L., Marinho, H.S., Norberto, F. (2000) Os compostos N-nitroso e o cancro. Química, 79, 30-34.
- Antunes, F., Salvador, A., Marinho, H.S., Pinto, R.E. (1994) A mathematical model for lipid peroxidation in inner mitochondrial membranes. Travaux de Laboratoire (Instituto Rocha Cabral), XXXIV, suppl. T-I, 1-55.[
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Book Chapters
- Antunes, F., Soares, H., Marinho, H.S. (2020) Oxigénio: da evolução dos seres vivos à medicina redox, in Os Elementos em Ciências - uma viagem pela Tabela Periódica (Mourato, A., Carvalho, A.P., Martins, F., Pamplona, M.T. ed.), pp. 51-52, Edições Ciências ULisboa. ISBN 978-972-9348-21-1 (paperback); 978-972-9348-22-8 (e-book).
- Praça, F.S., Marinho, H.S., Martins, M.B.F., Gaspar, R.S., Corvo, M.L., Medina, W. (2017) Current aspects of breast cancer therapy and diagnosis based on a nanocarrier approach, in Nanostructures for Cancer Therapy (Alexandru Mihai Grumezescu and Anton Ficai, ed.) Chapter 27, pp.749-774. Elsevier. doi: 10.1016/B978-0-323-46144-3.00027-1
- Gomes, A.Q., Real, C., Antunes, F., Marinho, H.S., Nolasco, S. and Soares, H. (2017). Non-coding RNAs as critical players in regulatory accuracy, redox signaling and immune cell functions. In Current Developments in Biotechnology and Bioengineering, Book 9: Biotechnology in Human and Animal Health, (Vanete Thomaz-Soccol, Rodrigo R. Resende, Ashok Pandey, eds.), Chapter 10, pp.215–284, Elsevier. doi: 10.1016/b978-0-444-63660-7.00010-3
- Corvo, M.L., Marinho, H.S., Martins, M.B.F. (2016) Nanomedicines as a strategy for the therapeutic use of superoxide dismutases, in Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits. (Nancy H. Phillips, ed.), Chapter 4, pp.135-170. NY: Nova Publishers.
- Marinho, H.S., Antunes F. (2015) Metabolism of superoxide radical and hydrogen peroxide in mitochondria in Mitochondria in Liver Disease (Derick Han and Neil Kaplowitz eds) Chapter 1, pp. 1- 28. Boca Raton: CRC Press.
- Oliveira-Marques, V., Marinho, H.S., Cyrne, L., Antunes, F., (2007) Steady-state titration with H2O2: Regulation of Plasma membrane and of NF-kB activation by H2O2. in Oxidative Stress: Clinical and Biomedical Implications, (Bashir Matata & Maqsood M. Elahi, ed.), pp. 59-67, Nova Publishers.
- Marinho, H.S., Pinto, R.E. (1997) Alguns aspectos da Química Orgânica com interesse em Bioquímica, In Bioquímica (Halpern, M.J. ed.), pp. 25-42, Lisboa: Lidel, edições técnicas.
- Pinto, R.E., Marinho, H.S. (1997) Breve História da Bioquímica, In Bioquímica (Halpern, M.J. ed.), pp. 13-23, Lisboa: Lidel, edições técnicas.
Monographs
- Marinho, H. Susana (2003) Bioquímica do Enxofre. Lisboa: Associação de Estudantes da FCUL. ISBN: 972-8008-88-0 [
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- Cyrne, Luísa, Marinho, H. Susana (2002) Métodos de Saturação/Competição: Introdução ao Radioimunoensaio e técnicas similares. Lisboa: Associação de Estudantes da FCUL. ISBN: 972-8008-85-6.[
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